336 research outputs found
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Beyond mystery babies : undiagnosis in a diagnostic age
This dissertation analyzes shifting understandings and lived experiences of undiagnosed disabilities, probing contemporary notions of bodily and intellectual difference. Thanks to new biomedical technologies and diagnostic frameworks, diagnoses are now possible for many people who would have received an ambiguous label of “multiple disabilities” in the past. This gives new forms of hope for diagnostic knowledge, while calling into question the social and practical significance of extremely rare diagnoses about which little is known.
This study asks what it means to be – and often to remain – undiagnosed in the contemporary U.S., and how this shapes broader beliefs, meanings, and practices surrounding disability. In a time of rising disability prevalence, complete with increased public awareness, shifting modes of clinical versus genetic identification of differences, and new forms of representation, what does it mean to remain undiagnosed? What might reside in these shadows? This analysis pays particular attention to family experiences, belonging, and the affective dimensions of disability in the everyday, and draws on anthropology, disability studies, and science and technology studies. Ultimately, this dissertation argues for a conceptual shift in approaching undiagnosis, calling for renewed attention to the complex social worlds of these individuals and their families as an emergent disability community.Anthropolog
Theology, News and Notes - Vol. 31, No. 03
Theology News & Notes was a theological journal published by Fuller Theological Seminary from 1954 through 2014.https://digitalcommons.fuller.edu/tnn/1085/thumbnail.jp
Desarrollo de un Marco de Adaptación de la Ingeniería de la Usabilidad al Proceso de Desarrollo Ágil SCRUM, Aplicado en el Departamento de Planificación del ECU911 de la Ciudad de Machala
La presente investigación contiene un marco de adaptación de la ingeniería de la Usabilidad al proceso de desarrollo ágil Scrum, aplicado en el Departamento de Planificación del ECU911 de la ciudad de Machala. Este proyecto surge de la necesidad que afronta actualmente la ingeniería de software por ausencia de usabilidad en los productos software desarrollados en la institución mencionada. Una vez definida las líneas de investigación, y profundizar en la teoría de la usabilidad en el proceso de desarrollo ágil y Scrum. Se redactó una propuesta teórica de la adaptación del marco y posterior se realizó su implementación mediante un caso práctico con personal del ECU911, para luego ser validado mediante encuestas. Finalmente se procede a formular las conclusiones que recopilan respuestas a varias preguntas planteadas en este artícul
The Bulletin, School of Nursing Alumni Association, 1978
Alumni Calendar
Recognition Plaque
A Letter from the President
Officers and Chairpersons
Jefferson - Past, Present and Future
Annual Reports
School of Practical Nursing
Sesqui Pledge Completed
Alumnae Data 1891-1978
Committee Reports
A.N.A. Convention Report
The Liberation of a POW
Resume of Alumni Meetings
Cocktails and Conversation
Class News
Luncheon Gusts - Class of 1978
Marriages
Births
In Memoriam
Alumni Notices
School of Nursing Notice
Recent advances in the application of stable isotopes as nutritional tools in aquaculture
From an ecological point of view, aquaculture systems consist of simple food webs having a limited number of nutritional sources. These characteristics facilitate the application of stable isotope ratios of carbon and nitrogen (δ13C and δ15N) to assess the flow of dietary components. Due to rapid and measurable bioaccumulation of the heavier stable isotopes, such isotopic shifts can be tracked at different times and at each trophic step to provide an indicator of what dietary components are being incorporated into animal tissue and how fast. The present manuscript presents results from recent, controlled nutritional experiments designed to quantify the relative contribution of dietary carbon and nitrogen supplied by different dietary items. Stable isotopes ratios were measured in a range of food sources and experimental animals. In a first experiment, juvenile shrimp Litopenaeus vannamei were reared on co-feeding regimes having different proportions of live biomass of the green macroalgae Ulva clathrata and inert feed in order to identify nutritional contributions to tissue growth using dual stable isotope analysis. In another trial, nitrogen stable isotopes were measured to explore the relative dietary nitrogen contributions from fish meal and pea meal (Pisum sativum) to the growth of white shrimp postlarvae fed low protein diets having different proportions of both ingredients. In a third, multidisciplinary experiment, Senegalese sole (Solea senegalensis) larvae were used as a model to evaluate the effect of different larval feeding regimes on (1) trypsinogen gene expression (ssetryp1), (2) trypsin and chymotrypsin activities and (3) changes in stable isotope composition to estimate the assimilation of dietary carbon from the larval diets
The Bulletin, School of Nursing Diploma Program Alumni Association, 1979
Alumni Calendar
Recognition Plaque
A Letter from the President
Officers and Chairpersons
The Future of Nursing Education at Jefferson
Annual Reports
Alumni Benefits
Memo from Your President
Resume of Alumni Association Meetings
Committee Reports
The Nursing Alumni Office Serves You
Profiles in Courage
Special Reports
Ways and Means Committee Report
38th General Hospital Reunion
College of Allied Health Sciences Achievement Award
Class News
Marriages
Births
In Memoriam
Alumni Notices
School of Nursing Notice
The future of evapotranspiration : global requirements for ecosystem functioning, carbon and climate feedbacks, agricultural management, and water resources
The fate of the terrestrial biosphere is highly uncertain given recent and projected changes in climate. This is especially acute for impacts associated with changes in drought frequency and intensity on the distribution and timing of water availability. The development of effective adaptation strategies for these emerging threats to food and water security are compromised by limitations in our understanding of how natural and managed ecosystems are responding to changing hydrological and climatological regimes. This information gap is exacerbated by insufficient monitoring capabilities from local to global scales. Here, we describe how evapotranspiration (ET) represents the key variable in linking ecosystem functioning, carbon and climate feedbacks, agricultural management, and water resources, and highlight both the outstanding science and applications questions and the actions, especially from a space-based perspective, necessary to advance them
The long lives of primates and the ‘invariant rate of ageing’ hypothesis
This work was supported by NIA P01AG031719 to J.W.V. and S.C.A., with additional support provided by the Max Planck Institute of Demographic Research and the Duke University Population Research Institute.Is it possible to slow the rate of ageing, or do biological constraints limit its plasticity? We test the ‘invariant rate of ageing’ hypothesis, which posits that the rate of ageing is relatively fixed within species, with a collection of 39 human and nonhuman primate datasets across seven genera. We first recapitulate, in nonhuman primates, the highly regular relationship between life expectancy and lifespan equality seen in humans. We next demonstrate that variation in the rate of ageing within genera is orders of magnitude smaller than variation in pre-adult and age-independent mortality. Finally, we demonstrate that changes in the rate of ageing, but not other mortality parameters, produce striking, species-atypical changes in mortality patterns. Our results support the invariant rate of ageing hypothesis, implying biological constraints on how much the human rate of ageing can be slowed.Publisher PDFPeer reviewe
Assessment of gene-by-sex interaction effect on bone mineral density
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.Sexual dimorphism in various bone phenotypes, including bone mineral density (BMD), is widely observed; however, the extent to which genes explain these sex differences is unclear. To identify variants with different effects by sex, we examined gene-by-sex autosomal interactions genome-wide, and performed expression quantitative trait loci (eQTL) analysis and bioinformatics network analysis. We conducted an autosomal genome-wide meta-analysis of gene-by-sex interaction on lumbar spine (LS) and femoral neck (FN) BMD in 25,353 individuals from 8 cohorts. In a second stage, we followed up the 12 top single-nucleotide polymorphisms (SNPs; p < 1 × 10(-5) ) in an additional set of 24,763 individuals. Gene-by-sex interaction and sex-specific effects were examined in these 12 SNPs. We detected one novel genome-wide significant interaction associated with LS-BMD at the Chr3p26.1-p25.1 locus, near the GRM7 gene (male effect = 0.02 and p = 3.0 × 10(-5) ; female effect = -0.007 and p = 3.3 × 10(-2) ), and 11 suggestive loci associated with either FN- or LS-BMD in discovery cohorts. However, there was no evidence for genome-wide significant (p < 5 × 10(-8) ) gene-by-sex interaction in the joint analysis of discovery and replication cohorts. Despite the large collaborative effort, no genome-wide significant evidence for gene-by-sex interaction was found to influence BMD variation in this screen of autosomal markers. If they exist, gene-by-sex interactions for BMD probably have weak effects, accounting for less than 0.08% of the variation in these traits per implicated SNP. © 2012 American Society for Bone and Mineral Research.Medtronic
NIH R01 AG18728
R01HL088119
R01AR046838
U01 HL084756
R01 AR43351
P01-HL45522
R01-MH-078111
R01-MH-083824
Nutrition and Obesity Research Center of Maryland P30DK072488
NIAMS/NIH F32AR059469
Instituto de Salud Carlos III-FIS (Spanish Health Ministry) PI 06/0034
PI08/0183
Canadian Institutes of Health Research (CIHR)
NHLBI HHSN268201200036C
N01-HC-85239
N01-HC-85079
N01-HC-85086
N01-HC-35129
N01 HC15103
N01 HC-55222
N01-HC-75150
N01-HC-45133
HL080295
HL087652
HL105756
NIA AG-023629
AG-15928
AG-20098
AG-027058
N01AG62101
N01AG62103
N01AG62106
1R01AG032098-01A1
National Center of Advancing Translational Technologies CTSI UL1TR000124
National Institute of Diabetes and Digestive and Kidney Diseases DK063491
EUROSPAN (European Special Populations Research Network)
European Commission FP6 STRP grant 018947
LSHG-CT-2006-01947
Netherlands Organisation for Scientific Research
Erasmus MC
Centre for Medical Systems Biology (CMSB)
Netherlands Brain Foundation (HersenStichting Nederland)
US National Institute for Arthritis, Musculoskeletal and Skin Diseases
National Institute on Aging R01 AR/AG41398
R01 AR050066
R21 AR056405
National Heart, Lung, and Blood Institute's Framingham Heart Study N01-HC-25195
Affymetrix, Inc. N02-HL-6-4278
Canadian Institutes of Health Research from Institute of Aging 165446
Institute of Genetics 179433
Institute of Musculoskeletal health 221765
Intramural Research Program of the NIH, National Institute on Aging
National Institutes of Health HHSN268200782096C
Hong Kong Research Grant Council HKU 768610M
Bone Health Fund of HKU Foundation
KC Wong Education Foundation
Small Project Funding 201007176237
Matching Grant
CRCG Grant
Osteoporosis and Endocrine Research Fund
Genomics Strategic Research Theme of The University of Hong Kong
Netherlands Organisation of Scientific Research NWO Investments 175.010.2005.011
911-03-012
Research Institute for Diseases in the Elderly 014-93-015
Netherlands Genomics Initiative (NGI)/Netherlands Consortium for Healthy Aging (NCHA) 050-060-810
Erasmus Medical Center and Erasmus University, Rotterdam
Netherlands Organization for the Health Research and Development (ZonMw)
Research Institute for Diseases in the Elderly (RIDE)
Ministry of Education, Culture and Science
Ministry for Health, Welfare and Sports
European Commission (DG XII)
Municipality of Rotterdam
German Bundesministerium fur Forschung und Technology 01 AK 803 A-H
01 IG 07015
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